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Most sedatives, including alcohol and Valium, work by binding to gamma-aminobutyric acid receptors (GABAA) in the central nervous system, resulting in an increase in inhibitory signals in the brain. Quaaludes bind to a different segment of the GABAA receptor, but have similar sedative effects.
Methaqualone (Quaaludes) is absorbed through the gastrointestinal tract. The effects begin to take place 20-45 minutes after ingestion. The high can last between 4 and 8 hours, but will depend on how much the user took. Because the drug can cause sedation, the typical user will force them self to stay awake, once the drowsiness has subsided, the user will feel a dissociative high. Users claim the methaqualone (Quaaludes) causes a loss of inhibitions, a sense of wellbeing, and an altogether euphoric and mellow high.
